Choroidal neovascularization induces retinal edema and its treatment addresses this problem

Choroidal Neovascularization Induces Retinal Edema and its Treatment Addresses this Problem

405 After some years of experience with treatment of choroidal neovascularization (CNV) with intravitreal injections, BLOCKINwe BLOCKINnow BLOCKINbetter BLOCKINunderstand BLOCKINhow BLOCKINCNV BLOCKINalters vision and how treatments work. A clear‑sighted observation BLOCKINwill BLOCKINclarify BLOCKINthat BLOCKINCNVs BLOCKINare BLOCKINable BLOCKINto BLOCKINalter BLOCKINthe retina BLOCKINand BLOC...

Mechanisms of retinal and choroidal neovascularization.

Current choroidal neovascularization treatment.

PURPOSE This paper aims to describe the current situation of choroidal neovascularization (CNV) treatment. PROCEDURES MEDLINE (2001-2013) was searched for original research studies (phase I, II, III), abstracts and review articles concerning CNV therapy, and other related articles. Selected information from related websites was also included. RESULTS The management of CNV was developed thro...

Retinal Inhibition of CCR3 Induces Retinal Cell Death in a Murine Model of Choroidal Neovascularization

Inhibition of chemokine C-C motif receptor 3 (CCR3) signaling has been considered as treatment for neovascular age-related macular degeneration (AMD). However, CCR3 is expressed in neural retina from aged human donor eyes. Therefore, broad CCR3 inhibition may be harmful to the retina. We assessed the effects of CCR3 inhibition on retina and choroidal endothelial cells (CECs) that develop into c...

Systemic rapamycin inhibits retinal and choroidal neovascularization in mice.

PURPOSE Rapamycin exhibits significant antitumor/antiangiogenic activity that is coupled with a decrease in vascular endothelial growth factor (VEGF) production and a reduction in the response of vascular endothelial cells to stimulation by VEGF. VEGF plays a significant role in neovascular pathologies of the eye, thus we tested the possibility of using rapamycin to inhibit retinal and choroida...